Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1003-91-4, name is 2,4,5-Tribromo-1-methylimidazole, A new synthetic method of this compound is introduced below., Computed Properties of C4H3Br3N2
2,4,5-tribromo-1-methyl-imidazole (1) (0.5g, 1.56mmol) and trimethyloxonium tetrafluoroborate (0.25g, 1.72mmol) in a Schlenk flask was charged with dichloromethane (30mL). The mixture was stirred overnight at room temperature to afford a colorless solid. The volatiles were removed in vacuum and the resulted solid was washed with diethyl ether (2¡Á15mL) and dried under vacuum to give 3 as colorless powder. Yield: 0.60g (91%). Mp: 304C. 1H NMR (DMSO-d6, 500MHz, delta, ppm): 3.78 (s, 6H, N-CH3). 13C NMR (DMSO-d6, 125MHz, delta, ppm): 38.1 (N-CH3), 112.0 (4,5-C-Br), 124.9 (C2-Br). IR (KBr, cm-1): 1637(m), 1554(m), 1504(s), 1445(m), 1396(m), 1329(m), 1295(m), 1056(vs), 1034(vs), 813(w), 641(w), 522(w). ESI MS: m/z 332.8081 [M-(BF4) ]+.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Avinash, Iruthayaraj; Gupta, Vivek; Karthik, Vedhagiri; Anantharaman, Ganapathi; Journal of Organometallic Chemistry; vol. 851; (2017); p. 104 – 114;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem