Adding a certain compound to certain chemical reactions, such as: 20034-00-8, name is (5-Nitro-1H-benzo[d]imidazol-2-yl)methanol, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 20034-00-8, Formula: C8H7N3O3
N-Methyl-2-methanol-5-nitrobenzimidazole 53 was prepared according to using the procedure by Harisha et al. [28]. A solution of 5-nitro-(1H-benzimidazole-2-yl)-methanol 30 (0.86 g, 4.50 mmol), and sodium hydroxide (0.18 g, 4.50 mmol) were stirred in dry acetone (20 mL) for 30 min. Then, iodomethane (0.64 g, 4.50 mmol) was added and the mixture was stirred for 24 h. The reaction mixture was concentrated to a quarter and then poured into ice-cold water. The solid was filtered and washed with 50% HCl to neutralize the excess potassium carbonate. The solid was washed with cold water (100 mL) and aqueous ethanol. The product was purified by column chromatography (9:1 chloroform/ethanol) to give the desired product (FAS50) as an yellow crystals Yield 19%.
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Reference:
Article; Alasmary, Fatmah A.S.; Snelling, Anna M.; Zain, Mohammed E.; Alafeefy, Ahmed M.; Awaad, Amani S.; Karodia, Nazira; Molecules; vol. 20; 8; (2015); p. 15206 – 15223;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem