Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 87233-54-3, name is 2-Chloro-1-(2-ethoxyethyl)-1H-benzo[d]imidazole, A new synthetic method of this compound is introduced below., name: 2-Chloro-1-(2-ethoxyethyl)-1H-benzo[d]imidazole
c) Intermediate (23) (15.1 g), 2-chloro-1-(2-ethoxyethyl)-1H-benzimidazol (13.5 g) and copper (3.84 g) were stirred at 150 C. for 4 hours. The mixture was taken up in CH2 Cl2 and filtered. The filtrate was washed with a NH4 OH solution and with water. The organic layer was dried, filtered and the solvent evaporated. The residue was purified by column chromatography over silica gel (eluent: CH2 Cl2 /CH3 OH 97/3). The pure fractions were collected and the solvent evaporated, yielding 20 g (77%) of (+-)-ethyl cis-4-[[1-(2-ethoxyethyl)-1H-benzimidazol-2-yl]amino]-2-(phenylmethyl)-1-piperidinecarboxylate (interm. 24).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Janssen Pharmaceutica N.V.; US6110939; (2000); A;,
Imidazole – Wikipedia,
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