Related Products of 2302-25-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2302-25-2, name is 4-Bromo-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
To a solution of 4-bromo-1H-imidazole 1a (2 g, 13.70 mmol) in DMF (30 mL) was added 2,2-dimethyloxiraneIf (20 mL) and Cs2CO3 (8 g, 24.62 mmol). The mixture was stirred at 90 C overnight. Then the mixture was evaporatedto dryness. The residue was dissolved in DCM (30 mL), washed with water (10 mL*2) and brine (10 mL), dried overNa2SO4, filtered and concentrated to give the target compound 1-(4-bromo-1H-imidazol-1-yl)-2-methylpropan-2-ol 1b(2.7 g, pale yellow solid), yield: 90.6%.1H NMR(400 MHz, CDCl3) delta 7.33 (s, 1H), 6.94 (s, 1 H), 3.82 (s, 2H), 1.22 (s, 6H)
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-1H-imidazole, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Medshine Discovery Inc.; Quingdao Huanghai Pharmaceutical Co., Ltd.; WU, Chengde; ZHANG, Zhiliu; YU, Tao; (125 pag.)EP3042907; (2016); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem