Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 58089-25-1, name is 2-Mercapto-5-benzimidazolecarboxylic Acid, A new synthetic method of this compound is introduced below., HPLC of Formula: C8H6N2O2S
EXAMPLE 1 2-[3-(4-Acetyl-3-hydroxy-2-propylphenoxy)propyl-thio]benzimidazole-5-carboxylic acid A mixture of 2-mercaptobenzimidazole-5-carboxylic acid (3.25 g), 3-(4-acetyl-3-hydroxy-2-propylphenoxy)propylbromide (2.00 g) and potassium hydroxide (1.27 g) in ethanol (30 ml) was refluxed for 4 hours. Then, the reacting mixture was poured into ice-water, made acidic with concentrated hydrochloric acid and extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate and then evaporated. The resulting residue was purified by silica gel column chromatography, eluding with dichloromethane-ethyl acetate-methanol (10:2:1), and recrystallized from n-hexane-ethyl acetate to give the title compounds (3.00 g, 67.1%) as pale yellow crystals, mp 106-108 C. Analysis (%) for C22 H24 N2 O5 S: Calcd. (Found); C, 61.67 (61.76); H, 5.65 (5.89); N, 6.54 (6.26).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Kyorin Pharmaceutical Co., Ltd.; US4942245; (1990); A;,
Imidazole – Wikipedia,
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