In an article, author is Macchiarulo, A, once mentioned the application of 1072-63-5, Recommanded Product: 1-Vinyl-1H-imidazole, Name is 1-Vinyl-1H-imidazole, molecular formula is C5H6N2, molecular weight is 94.1145, MDL number is MFCD00005297, category is imidazoles-derivatives. Now introduce a scientific discovery about this category.
1,4-benzothiazine and 1,4-benzoxazine imidazole derivatives with antifungal activity: A docking study
We have recently described the synthesis and antifungal activity of a series of 1,4-benzothiazine and 1,4-benzoxazine imidazole derivatives that mainly showed in vivo activity against a murine experimental model of candidiasis but that very often lacked in vitro activity. Here, we report a docking study of a representative set of our molecules in a 3D model of CYP51 of Candida albicans (CA-CYP51). The model was constructed on the basis of the sequence homology relationship with the recently reported crystal structure of the CYP51 of Mycobacterium tuberculosis (MT-CYP51). (C) 2002 Elsevier Science Ltd. All rights reserved.
If you are interested in 1072-63-5, you can contact me at any time and look forward to more communication. Recommanded Product: 1-Vinyl-1H-imidazole.