Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 693-98-1, Name is 2-Methyl-1H-imidazole, molecular formula is C4H6N2. In an article, author is Marzouk, Adel A.,once mentioned of 693-98-1, Computed Properties of C4H6N2.
Design, synthesis and anticonvulsant activity of new imidazolidindione and imidazole derivatives
New imidazolidindiones and tetra-substituted imidazole derivatives were designed, synthesized, and evaluated for the anticonvulsant activity through pentylenetetrazole (PTZ)-induced seizures and maximal electroshock (MES) tests using valproate sodium and phenytoin sodium as reference drugs, respectively. Most of the target compounds showed excellent activity against pentylenetetrazole (PTZ)-induced seizures with fair to no-activity against MES. Compounds 3d, 4e, 11b, and 11e showed higher activity (120%) than that of valproate sodium in PTZ model. Almost all compounds showed no neurotoxicity, as indicated by the rotarod test. Estimation of physicochemical properties and pharmacokinetic profiles of the target compounds were studied. The chemical structures of the target compounds were characterized by different spectrometric methods and elemental ana-lysis.
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