One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 641571-11-1, Name is 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline, formurla is C11H10F3N3. In a document, author is Li, H, introducing its new discovery. SDS of cas: 641571-11-1.
Remarkable rate acceleration of water-promoted nucleophilic substitution of Baylis-Hillman acetate: a facile and highly efficient synthesis of N-substituted imidazole
Without additional reagents, the Baylis-Hillman acetates 2 underwent nucleophilic Substitution reaction with imidazole readily in aqueous THF solution to afford the corresponding N-substituted imidazole derivatives 3 in good to excellent yields. Moreover, the reaction between the in situ generated DABCO salt of Baylis-Hillinan acetates 4 and imidazole occurs in aqueous THF providing the S(N)2 type products 5. The simpler operational procedure, better stereoselectivity and higher efficiency over conventional method make the present protocol practical for the preparation of imidazole derivatives. (c) 2005 Elsevier Ltd. All rights reserved.
I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 641571-11-1 help many people in the next few years. SDS of cas: 641571-11-1.