Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 1072-62-4, Name is 2-Ethyl-1H-imidazole. In a document, author is Tanitame, A, introducing its new discovery. Category: imidazoles-derivatives.
Synthesis and antibacterial activity of novel and potent DNA gyrase inhibitors with azole ring
The 4-piperidyl moiety and the pyrazole ring in 1-(3-chlorophenyl)-5-(4-phenoxyphenyl)-3-(4-piperidyl)pyrazole 2, which has previously shown improved DNA gyrase inhibition and target-related antibacterial activity, were transformed to other groups and the in vitro antibacterial activity of the synthesized compounds was evaluated. The selected pyrazole, oxazole and imidazole derivatives showed moderate inhibition against DNA gyrase and topoisomerase IV with similar IC50 values (IC50 = 9.4-25 mug/mL). In addition, many of the pyrazole, oxazole and imidazole derivatives synthesized in this study exhibited potent antibacterial activity against quinolone-resistant clinical isolates and coumarin-resistant laboratory isolates of Gram-positive bacteria with minimal inhibitory concentration values equivalent to those against susceptible strains. (C) 2004 Elsevier Ltd. All rights reserved.
I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 1072-62-4 help many people in the next few years. Category: imidazoles-derivatives.