Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, HPLC of Formula: C13H10N2716-79-0, Name is 2-Phenyl-1H-benzo[d]imidazole, SMILES is C1(C2=CC=CC=C2)=NC3=CC=CC=C3N1, belongs to imidazoles-derivatives compound. In a article, author is Li, Qing, introduce new discover of the category.
Discovery of Novel 2-(piperidin-4-yl)-1H-benzo[d]imidazole Derivatives as Potential Anti-Inflammatory Agents
A novel 2-(piperidin-4-yl)-1H-benzo[d]imidazole derivative 5 with good anti-inflammatory activity was identified from our in-house library. Based on hit compound 5, two series of 2-(piperidin-4-yl)-1H-benzo[d]imidazole derivative 6a-g and 7a-h were designed and synthesized as novel anti-inflammatory agents. Most of synthesized compounds exhibited good inhibitory activity on NO and TNF- production in LPS-stimulated RAW 264.7 macrophages, in which the compound 6e showed most potent inhibitory activity on NO (IC50=0.86m) and TNF- (IC50=1.87m) production. Further evaluation revealed that compound 6e displayed more potent in vivo anti-inflammatory activity than ibuprofen did on xylene-induced ear oedema in mice. Additionally, Western blot analysis revealed that compound 6e could restore phosphorylation level of IB and protein expression of p65 NF-B in LPS-stimulated RAW 264.7 macrophages.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 716-79-0. HPLC of Formula: C13H10N2.