Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 144689-94-1, Name is Diethyl 2-propyl-1H-imidazole-4,5-dicarboxylate, molecular formula is , belongs to imidazoles-derivatives compound. In a document, author is Tripathi, Tanvee, Computed Properties of C12H18N2O4.
QSAR studies on hetaryl imidazoles derivatives as novel dual inhibitors of vascular endothelial growth factor receptors I and II
The QSAR studies have been carried out on 19-hetaryl imidazoles derivatives, which were reported as inhibitor of vascular endothelial growth factor receptors (VEGFR). The present study was undertaken to determine the physico chemical parameters, which govern the anticancer activity of the given series of drug molecules. The best QSAR model thus obtained, have high statistical significance (> 99.9 %) and moderate correlation coefficient (r = 0.85) led us to know that the activity of these compounds is mainly influenced by substitutions (R) done at meta position of benzene ring and presence of 4-pyridine group at Ar position is found to be important for activity of given series of drug molecules.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 144689-94-1, in my other articles. Computed Properties of C12H18N2O4.