Synthetic Route of 288-32-4, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 288-32-4, Name is 1H-Imidazole, SMILES is C1=NC=CN1, belongs to imidazoles-derivatives compound. In a article, author is Zhong, Min, introduce new discover of the category.
Discovery of ravidasvir (PPI-668) as a potent pan-genotypic HCV NS5A inhibitor
This Letter describes the synthesis, representative structure activity relationship (SAR), activity and PK profiles of a series of functionalized benzimidazole-naphthylene-imidazole derivatives as HCV NS5A inhibitors. This effort successfully led to the discovery of ravidasvir (PPI-668), which has been well tolerated and shown high sustained viral response rates as a key component in all-oral combination regimens in multiple human clinical trials. (C) 2016 Elsevier Ltd. All rights reserved.
Synthetic Route of 288-32-4, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 288-32-4 is helpful to your research.