Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 16079-88-2, Name is 1-Bromo-3-chloro-5,5-dimethylimidazolidine-2,4-dione, molecular formula is , belongs to imidazoles-derivatives compound. In a document, author is Albertshofer, Klaus, Product Details of 16079-88-2.
Regioselective Electrophilic Fluorination of Rationally Designed Imidazole Derivatives
We report the regioselective and direct functionalization of rationally designed imidazole derivatives through electrophilic fluorination with N-fluorobenzenesulfonimide enabled via in situ deprotonation with lithium 2,2,6,6-tetramethylpiperidine. Aided by a controlled protecting group switch, we were able to effectively target both the reactive 5- as well as the difficult to target 4-position of these molecules, leading to a series of fluorinated polysubstituted imidazoles in gram scale.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 16079-88-2, in my other articles. Product Details of 16079-88-2.