23996-25-0, Name is 2-Ethyl-4-methyl-1H-imidazole-1-propanenitrile, molecular formula is C9H13N3, belongs to imidazoles-derivatives compound, is a common compound. In a patnet, author is Jayabharathi, Jayaraman, once mentioned the new application about 23996-25-0, Safety of 2-Ethyl-4-methyl-1H-imidazole-1-propanenitrile.
Studies on interaction between an imidazole derivative and bovine serum by spectral methods
The interaction between a trifluoromethyl substituted imidazole derivative 2-(4-(trifluorometh yl)phenyl)-1-phenyl-1H-imidazo[4,5-f] [1,10] phenanthroline (tfmppip) and bovine serum albumin (BSA) was investigated by solution spectral studies. The observed experimental result shows that the imidazole derivative has strong ability to quench the fluorescence of BSA by forming complex which is stabilized by electrostatic interactions. The effective quenching constants (k(sv)) were 2.79 x 10(4), 2.51 x 10(4), and 2.32 x 10(4) at 301, 310 and 318 K respectively. The Stern-Volmer quenching constant (K-sv), binding site number (n), apparent binding constant (K-A) and corresponding thermodynamic parameters (Delta G, Delta H and Delta S) were calculated. The distance between the donor (BSA) and acceptor (tfmppip) was obtained according to fluorescence resonance energy transfer (FRET). Conformational changes of BSA were observed from synchronous fluorescence technique. The effect of metal ions such as Cu2+, Zn2+, Ca2+, Mg2+, Ni2+, Co2+ and Fe2+ on the binding constants between the imidazole derivative and BSA were also studied. (C) 2012 Elsevier B.V. All rights reserved.
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