Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 288-32-4, Name is 1H-Imidazole, molecular formula is C3H4N2, belongs to imidazoles-derivatives compound, is a common compound. In a patnet, author is Pastor, Isidro M., once mentioned the new application about 288-32-4, Safety of 1H-Imidazole.
Isoprene-Mediated Lithiation of 1-Alkylimidazoles: Chiral Induction of the Alkyl Substituent
The isoprene-mediated lithiation of imidazoles bearing a secondary alkyl substituent at the nitrogen (7, 8 and 13) and the subsequent nucleophilic addition to different electrophiles allows the preparation of the corresponding 2-functionalized imidazoles 10, 11 and 14. The presence of a stereogenic center in the alkyl substituent induces diastereoselection during the nucleophilic addition step with a prochiral electrophile (i.e. pivalaldehyde), producing the expected imidazole derivative with excellent overall yield, but low de (up to 26%).
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