820959-17-9, Name is Ac-Beta-Ala-His-Ser-His-OH, molecular formula is C20H28N8O7, belongs to imidazoles-derivatives compound, is a common compound. In a patnet, author is Fresneda, Pilar M., once mentioned the new application about 820959-17-9, Safety of Ac-Beta-Ala-His-Ser-His-OH.
An iminophosphorane-based approach for the synthesis of spiropyrrolidine-imidazole derivatives
A method based on the reaction of an E-phosphazide, an intermediate in the Staudinger reaction between triphenylphosphine and an azide, with heterocumulenes allows the one-pot, two-component synthesis of a number of pyrrole-imidazole derivatives. The procedure, which involves sequential treatment of the appropriate a-azido ester with triphenylphosphine and isocyanate leads to the hydantoin product after aqueous work-up. The cyclization conditions can also be adapted for the synthesis of thiohydantoins by using isothiocyanates. These hybrids pyrrole-thiohydantoins undergo a novel oxidative spirocyclization by action of DDQ to give a tricyclic derivative (pyrrole-pyrrolidine-imidazole), which displays an interesting cytotoxic activity. (c) 2006 Elsevier Ltd. All rights reserved.
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