Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 25676-75-9, Name is 4-Bromo-1-methylimidazole. In a document, author is Tseng, Chih-Hua, introducing its new discovery. COA of Formula: C4H5BrN2.
Identification of furo[3 ‘,2 ‘:3,4]naphtho[1,2-d]imidazole derivatives as orally active and selective inhibitors of microsomal prostaglandin E-2 synthase-1 (mPGES-1)
This study describes the synthesis and anti-inflammatory effects of furo[3′, 2′:3,4]naphtho[1,2-d] imidazole derivatives. Among these furo[3′, 2′:3,4]naphtho[1,2-d]imidazole derivatives, 2-(4-methoxyphenyl)furo [3′, 2’:3,4]naphtho[1,2-d]imidazole (12) exhibited a strong inhibitory activity against LPS-induced PGE(2) production, with an IC50 value of 47 nM. Compound 12 is then further examined for its inhibitory effects in the protein expression of COX-2 and microsomal prostaglandin E-2 synthase-1 (mPGES-1) in Raw 264.7 cells. Our results indicate that compound 12 was capable against inhibiting LPS-induced mPGES-1 protein expression at a concentration of 1.0 mu M and no inhibitory effect in COX-2 expression. The sepsis-induced PGE(2) production in rat serum decreased similar to 250% by the pretreatment of 12 at 10 mg/kg. These results are especially important since compound 12 exhibited good oral bioavailability (72%) and was not cytotoxic at a concentration of 10.0 mu M. Therefore, compound 12 is a highly selective mPGES-1 inhibitor that can serve as a lead for the development of novel oral anti-inflammatory drug candidates.
I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 25676-75-9 help many people in the next few years. COA of Formula: C4H5BrN2.