Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 822-55-9, Name is 4-(Hydroxymethyl)imidazole, molecular formula is C4H6N2O, belongs to imidazoles-derivatives compound, is a common compound. In a patnet, author is Yue, Yuanyuan, once mentioned the new application about 822-55-9, Recommanded Product: 4-(Hydroxymethyl)imidazole.
Synthesis of imidazole derivatives and the spectral characterization of the binding properties towards human serum albumin
Small molecular drugs that can combine with target proteins specifically, and then block relative signal pathway, finally obtain the purpose of treatment. For this reason, the synthesis of novel imidazole derivatives was described and this study explored the details of imidazole derivatives binding to human serum albumin (HSA). The data of steady-state and time-resolved fluorescence showed that the conjugation of imidazole derivatives with HSA yielded quenching by a static mechanism. Meanwhile, the number of binding sites, the binding constants, and the thermodynamic parameters were also measured; the raw data indicated that imidazole derivatives could spontaneously bind with HSA through hydrophobic interactions and hydrogen bonds which agreed well with the results from the molecular modeling study. Competitive binding experiments confirmed the location of binding. Furthermore, alteration of the secondary structure of HSA in the presence of the imidazole derivatives was tested. (C) 2015 Elsevier B.V. All rights reserved.
We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 822-55-9. The above is the message from the blog manager. Recommanded Product: 4-(Hydroxymethyl)imidazole.