Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 1072-62-4, Name is 2-Ethyl-1H-imidazole, SMILES is CCC1=NC=CN1, in an article , author is PEDERSEN, M, once mentioned of 1072-62-4, HPLC of Formula: C5H8N2.
FORMATION AND ANTIMYCOTIC EFFECT OF CYCLODEXTRIN INCLUSION COMPLEXES OF ECONAZOLE AND MICONAZOLE
The stability constants between beta-cyclodextrin (beta-CD) and the two antimycotic imidazole derivatives, miconazole and econazole were measured. Increased ionization of the imidazole derivatives decreased the size of the stability constants. The same phenomenon was observed for miconazole and hydroxypropyl-beta-cyclodextrin. In addition, the type of solubility diagram obtained was dependent on the degree of ionization of the imidazole derivatives. A type Bs solubility diagram was obtained for econazole and beta-CD in buffer solution, pH 7.1. An econazole beta-CD complex with a molar ratio of 1:1 was isolated. In a fluid medium the antimycotic effect of the econazole beta-CD complex against a strain of Candida albicans was superior to the effect of a physical mixture of the two compounds. A small inhibitory effect of beta-CD on the growth of the test organism was observed.
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