Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 934-32-7, Name is 1H-Benzo[d]imidazol-2-amine, molecular formula is , belongs to imidazoles-derivatives compound. In a document, author is Chhetri, Abhijit, Quality Control of 1H-Benzo[d]imidazol-2-amine.
Synthesis, characterization and computational study on potential inhibitory action of novel azo imidazole derivatives against COVID-19 main protease (M-pro: 6LU7)
A series of six novel imidazole anchored azo-imidazole derivatives (L1-L6) have been prepared by the simple condensation reaction of azo-coupled ortho-vaniline precursor with amino functionalised imidazole derivative and the synthesized derivatives (L1-L6) have been characterized by different analytical and spectroscopic techniques. Molecular docking studies were carried out to ascertain the inhibitory action of studied ligands (L1-L6) against the Main Protease (6LU7) of novel coronavirus (COVID-19). The result of the docking of L1-L6 showed a significant inhibitory action against the Main protease (M-pro) of SARS-CoV2 and the binding energy (Delta G) values of the ligands (L1-L6) against the protein 6LU7 have found to be-7.7 Kcal/mole (L1),-7.4 Kcal/mole (L2),-6.7 Kcal/mole (L3),-7.9 Kcal/mole (L4),-8.1 Kcal/mole (L5) and-7.9 Kcal/mole (L6). Pharmacokinetic properties (ADME) of the ligands (L1-L6) have also been studied. (c) 2020 Elsevier B.V. All rights reserved.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 934-32-7, in my other articles. Quality Control of 1H-Benzo[d]imidazol-2-amine.