Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 288-32-4, name is 1H-Imidazole, A new synthetic method of this compound is introduced below., name: 1H-Imidazole
General procedure: A mixture of aryl imidazoles (0.5 mmol), arylboronic acid (1 mmol), K2CO3 (1 mmol), C-1 complex (5 mol %, 9.79 mg) in iso-propanol (1.5 mL) was stirred in a 50 mL oven dried round bottomed flask. After the completion of the reaction (monitored by TLC), the mixture was diluted with 20 mL water. The organic part was extracted with diethyl ether (3 20 mL) followed by drying over anhydrous Na2SO4, and the solvent was evaporated under reduced pressure to obtain the crude product. The residue was then purified with column chromatography using methanol/ethyl acetate (1:9) as eluent to afford the desired product. The purity of the compound was confirmed by 1H NMR, 13CNMR, MS, and melting point data. N-Phenyl imidazole (6a): 1H NMR (400 MHz, CDCl3, d ppm) 8.02 (s, 1H), 7.51-7.47 (m, 2H), 7.41-7.37 (m, 3H), 7.26 (s, 1H), 7.21 (s, 1H). 13C NMR (100 MHz, CDCl3, d ppm): 138.1, 135.9, 130.5, 130.1, 127.6, 121.8, 118.5.
The synthetic route of 288-32-4 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Gogoi, Ankur; Sarmah, Gayatri; Dewan, Anindita; Bora, Utpal; Tetrahedron Letters; vol. 55; 1; (2014); p. 31 – 35;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem