14741-71-0, name is Ethyl 2-(1H-benzo[d]imidazol-2-yl)acetate, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Computed Properties of C11H12N2O2
General procedure: To the dry solid of compound 3 (2.04 g, 0.01 mol) ammonium acetate (0.50 g) eithercyclophentanone (0.78 g, 0.01 mol) or cyclohexanone (0.92 g, 0.01 mol) were added. Thereaction mixture was heated in an oil bath at 120 oC for 1 h then left to cool. The product wastriturated with ethanol and the formed solid product was collected by filtration.Ethyl 2-(1H-benzo[d]imidazol-2-yl)-2-cyclopentylideneacetate (15a). Pale yellow crystals fromethanol; yield: 2.53 g (83%); m.p. 155 oC. IR, : 3459-3322 (NH), 3053 (CH aromatic), 2929,2863 (CH3, CH2), 1686 (CO), 1636 (C=N), 1630 (C=C). 1H-NMR: : 1.13 (t, 3H, J = 6.93 Hz,CH3), 1.18-1.24 (m, 4H, 2CH2), 2.19-2.21 (m, 4H, 2CH2), 4.22 (q, 2H, J = 6.93 Hz, CH2), 7.27-7.38 (m, 4H, C6H4), 8.32 (s, 1H, NH, D2O exchangeable). 13C NMR (DMSO): 16.2 (ester CH3),1.89-2.13 (2m 4CH2), 52.6 (ester CH2), 86.4, 90.6 (C=C), 120.3, 121.2, 123.2, 125.6, 128.6(C6H4), 164.8 (CO), 173.2 (C=N); Anal. calcd for C16H18N2O2: C, 71.09; H, 6.71; N, 10.36%.Found: C, 70.93; H, 6.93; N, 10.47%. MS: m/z: (%) 270 (M+, 36%).
The synthetic route of 14741-71-0 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Mohareb, Rafat M.; Gamaan, Marwa S.; Bulletin of the Chemical Society of Ethiopia; vol. 32; 3; (2018); p. 541 – 557;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem