Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 13275-42-8, name is 2-(2-Bromophenyl)-1H-benzo[d]imidazole, A new synthetic method of this compound is introduced below., Safety of 2-(2-Bromophenyl)-1H-benzo[d]imidazole
General procedure: First, 100 mmol of 2-(2-bromophenyl)imidazole derivatives introduced into 300 ml of triethylamine and 200 ml of DMF. And stirring continuously added to 200 ml alkyne, 5 mmol triphenylphosphine and 5 mmol of copper iodide (I) and 2 mmol palladium(II) acetate. The reaction mixture was then stirred for 20 hours at 80 . After cooling, the reaction mixture was diluted with 400 ml of methylene chloride, to separate a solid, by filtration through a bed of salt C and the filtrate was evaporated to dryness. The residue was dissolved in 300 ml of methylene chloride, 100 ml of concentrated aqueous ammonia with individual cleaning solution three times, and then washed three times with 100 ml of water, and dried over magnesium sulfate. With spherical fractionating tube distillation or sublimation, resulting in the manipulation of the vacuum pump oil / solids release low-boiling components and trace metals.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; MERCK PATENT GMBH; STOESSEL, PHILIPP; HEIL, HOLGER; JOOSTEN, DOMINIK; PFLUMM, CHRISTOF; GERHARD, ANJA; BREUNING, ESTHER; (214 pag.)TWI520958; (2016); B;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem