Related Products of 641571-11-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 641571-11-1, name is 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
A suspension of 1 (0.10 g, 0.40 mmol), 51 (0.13 g, 0.54 mmol), Pd2(dba)3 (25 mg, 0.027 mmol), t-tert-buty phosphine (IM in toluene; 0.1 mL, 0.10 mmol) and potassium tert- butoxide (0.25 g, 2.2 mmol) in dioxane/DMF (1/1; 6 mL) was sealed in a microwave reaction tube and irradiated with microwave at 160 0C for 30 min. After cooling to room temperature, the resulting mixture was filtered and the filtered solid washed with DCM. The filtrate was concentrated and the residue purified by HPLC. The fractions were combined and poured into saturated NaHCO3 solution (20 mL). The combined aqueous layers were extracted withEtOAc (2 x 20 mL) and the combined organic layers washed with brine, dried over anhydrous Na2SO4 and filtered. The filtrate was concentrated and the residue re-dissolved in minimum amount of EtOAc and hexanes added until solid precipitated. After filtration, the title compound was obtained as a light brown solid (23 mg, 13%).[0264] 1K NMR (500 MHz, DMSO-J6): delta 2.20 (s, 3H), 2.33 (s, 3H), 6.93 (dd, J = 3.6, 1.7 Hz, IH), 7.41 (dd, J = 3.6, 2.3 Hz, IH), 7.44 (s, 2H), 7.50 (s, IH), 7.97 (s, IH), 8.20 (d, J = 0.8 Hz, IH), 8.27 (s, IH), 8.46 (s, IH), 11.84 (s, IH)MS (ES+): m/z 455 (M+H)+
The synthetic route of 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline has been constantly updated, and we look forward to future research findings.
Reference:
Patent; TARGEGEN INC.; WO2009/49028; (2009); A1;,
Imidazole – Wikipedia,
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