Extended knowledge of 615-16-7

The synthetic route of 615-16-7 has been constantly updated, and we look forward to future research findings.

Related Products of 615-16-7, These common heterocyclic compound, 615-16-7, name is 2-Hydroxybenzimidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of 4a or 4b (1 equiv.) and K2CO3 (3 equiv.) in DMF was stirred at 90C for 1h, then the solution was allowed to cool to 60C and was added different substituted 2-chloro-1-phenylethan-1-one (3 equiv.). The mixture was stirred at 60C for another 3h and allowed to cool to room temperature. The saturated NH4Cl solution was added to quench the reaction. The mixture was diluted with water and was extracted with ethyl acetate to afford the crude product that was purified by flash column chromatography on silica gel to yield the target products

The synthetic route of 615-16-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Zou, Yi; Wang, Yan; Wang, Fang; Luo, Minghao; Li, Yuezhen; Liu, Wen; Huang, Zhangjian; Zhang, Yihua; Guo, Wenjie; Xu, Qiang; Lai, Yisheng; European Journal of Medicinal Chemistry; vol. 138; (2017); p. 199 – 211;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem