Reference of 13750-62-4,Some common heterocyclic compound, 13750-62-4, name is 1-Benzyl-2-methyl-1H-imidazole, molecular formula is C11H12N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: 1-Benzyl-2-methylimidazole (0.32 cm3, ?2 mmol) was dissolved in acetonitrile (10 cm3) and then slowly added to warm solution of PdCl2 (0.18 g, 1 mmol) (in the synthesis of thiocyanate complex the NH4SCN (0.15 g, 2 mmol) was added) in acetonitrile (30 cm3). The mixture was refluxed for about 2 h and after the time the reaction solution was filtered and yellow single crystals were obtained by slow evaporation of the solvent. Yield: 88% for chloride complex (1) and 92% for thiocyanate analog (2).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Benzyl-2-methyl-1H-imidazole, its application will become more common.
Reference:
Article; Ma?ecki; Maro?; Polyhedron; vol. 50; 1; (2013); p. 452 – 460;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem