Application of 104619-51-4, These common heterocyclic compound, 104619-51-4, name is Di(1H-imidazol-1-yl)methanimine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To 4-[3-tert-Butylsulfanyl-2-(2,2-dimethyl-propyl)-5-(pyridin-2-ylmethoxy)-indol-l- ylmethylj-benzoic acid hydrazide (0.05g, O. lOmmol) in DMF (lmL) was added C-(Di-imidazol-l- yl)-methyleneamine (0.08g, 0.50mmol), and the reaction was heated at 85C for 3 hours. The mixture was cooled to room temperature and partitioned between water and EtOAc. The aqueous layer was extracted with EtOAc, and the combined organic layers were dried over MgS04, filtered, and concentrated. The residue was purified on silica gel (EtOAc:hexane gradient) to give the desired product.
The synthetic route of 104619-51-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; AUTOIMMUNE PHARMA LLC; BENISON, Jeffrey; (157 pag.)WO2018/152405; (2018); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem