A new synthetic route of 28890-99-5

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5H-Benzo[d]benzo[4,5]imidazo[1,2-a]imidazole, and friends who are interested can also refer to it.

Related Products of 28890-99-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 28890-99-5 name is 5H-Benzo[d]benzo[4,5]imidazo[1,2-a]imidazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

a) 31.7 g (96.1 mmol) diiodobenzene, 14.9 g (72.1 mmol) 6H-benzimidazolo[1,2- a]benzimidazole, 23.5 g (72.1 mmol) cesium carbonate, 1.83 g (9.61 mmol) cupper (I) iodide, 2.21 g (19.3 mmol) L-proline in 400 ml DMSO was stirred under nitrogen at 100 C for3 h. The reaction mixture was poured in 600 ml water and the product was filtered off. The product is washed with water and ethanol. 100 ml diethyl ether is added and the mixture is stirred for 3 h. Product is filtered off and is washed with ether. To the product 200 ml dichloromethane is added and the mixture is refluxed for 2 h. The mixture is filtered and washed with dichloromethane. The solvent of the filtrate is distilled off. Colum chromatog10 raphy on silica gel with toluene/ethyl acetate 19/1 gave the product 6.47 g (22 %).1H NMR (400 MHz, DMSO-d6): = 8.32 (t, J =1.8 Hz, IH), 8.19-8.24 (m, 2H), 7.93-7.96 (m,IH) 7.86-7.88 (m, IH), 7.63-7.68 (m 2H), 7.38-7.49 (m, 3H), 7.28-7.36 (m, 2H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5H-Benzo[d]benzo[4,5]imidazo[1,2-a]imidazole, and friends who are interested can also refer to it.

Reference:
Patent; IDEMITSU KOSAN CO., LTD.; SCHAeFER, Thomas; STENGEL, Ilona; HEINEMEYER, Ute; NAGASHIMA, Hideaki; BARDON, Kristina; WO2015/150234; (2015); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem