Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 17289-25-7, name is (1-Methyl-1H-imidazol-4-yl)methanol, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C5H8N2O
To a solution of intermediate 111 (400mg, 1. [02MMOL)] in DMF [(20ML)] was added portionwise sodium hydride (60percent in mineral oil, 101mg, 2. [55MMOL)] and the mixture was stirred at room temperature for 20 minutes. Intermediate 22 (173mg, 1. [32MMOL)] was then added and the mixture was heated at [60¡ãC] for 3 days and then poured into water. After extraction with [CH2CI2,] the organic phase was dried over Na2SO4 and concentrated under reduced pressure. The residue was purified by chromatography on silica gel eluting with [CH2CI2/MEOH] (90: 10). After trituration with diisopropyl oxide, the title compound was obtained as a yellow solid (130mg, 26percent); m. p. [217¡ãC] ; TOF MS ES + exact mass calculated for [C3OH26N6O] : 487.2246 (MH+). Found: [487. 2247] (MH+).
According to the analysis of related databases, 17289-25-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2004/13135; (2004); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem