Application of 22884-10-2,Some common heterocyclic compound, 22884-10-2, name is 2-(1H-Imidazol-1-yl)acetic acid, molecular formula is C5H6N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of (3- { [(ethylimino)methylidene] amino } propyl)dimethylamine hydrochloride (EDC.HC1) (1.2 mmol), 1-hydroxybenzotriazole (HOBt) (1.2 mmol), N,N-diisopropylethylamine (0.35 ml, 2 mmol), 2-(1H-imidazol-1-yl)acetic acid (1.2 mmol), and 3-methyl-4-phenylaniline (1 mmol) in dimethylformamide (7 mL) was stirred for 36 hours at room temperature. Then the reaction mixture was treated withwater (35 mL), the crude product was filtered and purified by recrystallization from acetonitrile. Yield: 40%.The spectral data for Compound 30 is listed below: Compound 30:?HNMR(DMSO-d6): 5= 10.55 (s, 1H,NI]), 7.65 (s, 1H, CmidH), 7.45 (m, 4H, Cp,J]), 7.37 (m, 3H, CFhH) ,7. 17 (m, 2H, CFhH, CmiciH), 6.9 (d, 1H, CmiciH), 4.9 (s, 2H, CH2), 2.2 (s, 3H, CH3) ppm.LS-MS (m/z): calcd./found for [M+H] 292.16. 1/292.0.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(1H-Imidazol-1-yl)acetic acid, its application will become more common.
Reference:
Patent; MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH; SPRINGER, Wolfdieter; FIESEL, Fabienne C.; CAULFIELD, Thomas R.; (172 pag.)WO2018/23029; (2018); A1;,
Imidazole – Wikipedia,
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