Synthetic Route of 17286-47-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 17286-47-4, name is 2-(1H-Imidazol-2-yl)ethanamine dihydrochloride, This compound has unique chemical properties. The synthetic route is as follows.
A mixture of 4-bromo-lH-pyrrolo[2,3-b]pyridine-2-carboxylic acid(200 mg, 0.830 mmol) in DMF (15 mL) was added hydroxybenzotriazole (HOBt) (224 mg, 1.66 mmol), EDOHC1 (318 mg, 1.66 mmol), TEA (420 mg, 4.15 mmol, 0.58m), the reaction mixture was stirred at 50 C for 0.5 hour, then added 2-(lH-imidazol-2-yl) ethanamine (305 mg, 1.66 mmol, 2 HC1 salt) into it and continued stirred for another 2.5 h to give a pale yellow suspension. LCMS showed the purity of the desired product (Rt = 0.600 min; MS Calc?d: 333.0; MS Found: 333.9 [M+H]+). The mixture was diluted with water (15 mL), then extracted with EtOAc (20 mL x2), the combined extracts was washed with brine (25 mL x2), dried over Na2S04, filtered and concentrated under reduced pressure to give N-(2-(lH-imidazol-2- yl)ethyl)-4-bromo-lH-pynOlo[2,3-b]pyridine-2-carboxamide (250 mg, purity: 92%, yield: 83%) as an off-white solid NMR (400 MHz, DMSO-r e) d 2.86-2.95 (2H, m), 3.52-3.65 (2H, m), 6.85-6.98 (2H, m), 7.15 (1H, s), 7.42 (1H, d, J= 5.2 Hz), 8.19 (1H, d, J= 4.8 Hz), 8.83 (1H, br s), 11.82 (1H, br s), 12.56 (1H, br s).
The chemical industry reduces the impact on the environment during synthesis 2-(1H-Imidazol-2-yl)ethanamine dihydrochloride. I believe this compound will play a more active role in future production and life.
Reference:
Patent; PETRA PHARMA CORPORATION; KESICKI, Edward A.; RAVI, Kannan Karukurichi; LINDSTROeM, Johan; PERSSON, Lars Boukharta; LIVENDAHL, Madeleine; VIKLUND, Jenny; GINMAN, Tobias; FORSBLOM, Rickard; RAHM, Fredrik; HICKEY, Eugene R.; DAHLGREN, Markus K.; GERASYUTO, Aleksey I.; (478 pag.)WO2019/126733; (2019); A1;,
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