These common heterocyclic compound, 16265-04-6, name is 2-Chloro-1H-imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C3H3ClN2
To a solution of 2-chloro-1H-imidazole (250 mg, 2.44 mmol) in DMF (5 mL) were added K2CO3 (1011 mg, 7.32 mmol) and tert-butyl (2-bromoethyl)carbamate (601 mg, 2.68 mmol), and the resulting mixture was stirred at 80 C. for 16 h then concentrated under reduced pressure. H2O (20 mL) was added, the mixture was extracted with EtOAc (3*10 mL), and the combined organic layers were washed with sat. aq. NaCl, dried over MgSO4, filtered and concentrated under reduced pressure. The residue was purified by SiO2 gel chromatography (0% to 5% MeOH in CH2Cl2) to give the title compound as a white solid (394 mg, 66%). MS (ES+) C10H16ClN3O2 requires: 245, found: 246 [M+H]+.
The synthetic route of 2-Chloro-1H-imidazole has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Board of Regents, The University of Texas System; LE, Kang; SOTH, Michael J.; JONES, Philip; CROSS, Jason Bryant; CARROLL, Christopher L.; MCAFOOS, Timothy Joseph; MANDAL, Pijus Kumar; US2019/298729; (2019); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem