Application of 51605-32-4, The chemical industry reduces the impact on the environment during synthesis 51605-32-4, name is Ethyl 5-methyl-1H-imidazole-4-carboxylate, I believe this compound will play a more active role in future production and life.
To a suspension of 60percent sodium hydride (3.12 g) which had been washed before with hexane in DMF (100 ml), ethyl 4-methylimidazole-5-carbonate (10.0 g) was added by portions at 0¡ãC. The mixture was allowed to be at room temperature and stirred for 1 hour under nitrogen atmosphere, and then, 1-iodopropane (13.9 g) was added dropwise to the mixture. After the mixture was stirred for 1 hour, water was added to the mixture, and the mixture was extracted with ethyl acetate twice. The organic layer was dried over magnesium sulfate, and the solvent was distilled off under reduced pressure. The obtained residue was separated and separated and purified by basic silica gel column chromatography (hexane-ethyl acetate = 3:1), to give ethyl 4-methyl-1-propylimidazole-5-carbonate (4.31 g) and ethyl 5-methyl-1-propylimidazole-4-carbonate (8.25 g). ethyl 4-methyl-1-propylimidazole-5-carbonate 1H-NMR (200 MHz, CDCl3) delta 0.91 (3H, t, J = 7.4 Hz), 1.39 (3H, t, J = 7.2 Hz), 1.69 to 1.87 (2H, m), 2.49 (3H, s), 4.19 (2H, t, J = 7.4 Hz), 4.33 (2H, q, J = 7.2 Hz), 7.44 (1H, s). ethyl 5-methyl-1-propylimidazole-4-carbonate 1H-NMR (200 MHz, CDCl3) delta 0.95 (3H, t, J = 7.4 Hz), 1.40 (3H, t, J = 7.4 Hz), 1.67 to 1.86 (2H, m), 2.54 (3H, s), 3.84 (2H, t, J = 7.4 Hz), 4.38 (2H, q, J = 7.4 Hz), 7.40 (1H, s).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 5-methyl-1H-imidazole-4-carboxylate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Takeda Chemical Industries, Ltd.; EP1422228; (2004); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem