Application of 14741-71-0,Some common heterocyclic compound, 14741-71-0, name is Ethyl 2-(1H-benzo[d]imidazol-2-yl)acetate, molecular formula is C11H12N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To a solution of compound 3 (2.04 g, 0.01 mol) in dimethylformamide (30 mL) either aniline(0.93 g, 0.01 mol) or 4-methylaniline (1.08 g, 0.01 mol) was added. The reaction mixture, ineach case, was heated under reflux for 4 h then poured onto ice/water mixture containing fewdrops of hydrochloric acid and the formed solid product was collected by filtration. 2-(1H-Benzo[d]imidazol-2-yl)-N-phenylacetamide (5a). Light brown crystals from ethanol;yield: 2.08 g (80%); m.p. 220-222 oC. IR, : 3472-3324 (2NH), 3050 (CH aromatic), 1680(C=O), 1648 (C=N), 1629 (C=C). 1H-NMR, : 4.93 (s, 2H, CH2), 7.25-7.41 (m, 9H, C6H5,C6H4), 8.26, 8.32 (2s, 2H, 2NH, D2O exchangeable). 13C NMR (DMSO): 54.8 (CH2), 119.2,120.8, 122.8, 123.6, 124.3, 125.2, 126.1, 127.3, 128.3, 129.2, (C6H5, C6H4), 164.8 (CO), 172.4(C=N); Anal. calcd for C15H13N3O: C, 71.70; H, 5.21; N, 16.72%. Found: C, 71.83; H, 5.08; N,16.82%. MS: m/z: (%) 251 (M+, 24%).
The synthetic route of 14741-71-0 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Mohareb, Rafat M.; Gamaan, Marwa S.; Bulletin of the Chemical Society of Ethiopia; vol. 32; 3; (2018); p. 541 – 557;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem