Related Products of 1849-02-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1849-02-1, name is 2-Chloro-1-methyl-1H-benzo[d]imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
Step 2 0.43 g (5.0 mmol) of piperazine and 0.24 g (1.0 mmol) of the compound obtained in Step 1 were placed in a dried round flask provided with nitrogen gas, followed by reacting the mixture at 150C for 30 mins. After cooling to room temperature, the reaction mixture was acidified with IN-HCl solution and washed with dichloromethane. The water layer was treated with IN-NaOH solution and extracted with dichloromethane. The formed organic layer was dried over anhydrous magnesium sulfate and concentrated under a reduced pressure, and the resulting residue was subjected to silica gel column chromatography (dichloromethaneimethanol^il) to obtain 0.15 g of l-methyl-2-(piperazin-l-yl)-benzoimidazole (yield: 69%).
The synthetic route of 2-Chloro-1-methyl-1H-benzo[d]imidazole has been constantly updated, and we look forward to future research findings.
Reference:
Patent; KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; CHEMON INC.; WO2008/153325; (2008); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem