Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 15965-31-8, name is 5-Chloro-1H-imidazole, This compound has unique chemical properties. The synthetic route is as follows., Safety of 5-Chloro-1H-imidazole
To a stirred mixture of intermediate E(3) (4.0 g, 11.1 mmol), KOH (0.93 g, 16.6 mmol) in DMSO (30 mL) was added chloroimmidazole (1.69 g, 16.6 mmol) at room temperature. The reaction mixture was stirred at 90 C for 18 h while monitoring by LC-MS and TLC. The reaction mixture was poured into crushed ice (50 g) and extracted with ethyl acetate (3 x 200 mL). The organic layer was washed with brine, dried over anhydrous sodium sulphate and concentrated under reduced pressure. The crude compound was purified by column chromatography (60-120 mesh silica) using 60-70% ethyl acetate in pet-ether to give tert-butyl 2-(2-(2-(4-chloro-lH-imidazol-l-yl)-5- nitrophenoxy)ethoxy)ethylcarbamate ( 3.0 g, 63.29%) as a yellow solid. LC-MS (M- 100)+ = 326.2. 1H NMR (400 MHz, CDC13) delta ppm 8.01-7.97 (2H, m), 7.88 (1H, s), 7.46- 7.44 (1H, d, J=8.8 Hz), 7.28-7.27 (1H, m), 4.92 (1H, s), 4.34-4.33 (2H, m), 3.86-3.83 (2H, m), 3.59-3.57 (2H, t, J=5.2 Hz), 3.37-3.34 (2H, m), 1.43 (9H, s).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 15965-31-8.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; BOY, Kenneth M.; GUERNON, Jason M.; MACOR, John E.; THOMPSON III, Lorin A.; WU, Yong-Jin; ZHANG, Yunhui; WO2012/9309; (2012); A1;,
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