Application of 31722-49-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 31722-49-3 as follows.
A mixture of (2R ,5R)-5-chloromethyl-4-{2-[6-(4-fluoro-benzyl)-3, 3-dimethyl-2, 3-dihydro-pyrrolo[3,2-b]pyridin- 1 -yl]-2-oxo-ethyl}-2-methyl-piperazine- 1 -carboxylic acid tert-butyl ester(0.10 g, 0.18 mmol), 2-cyanoimidazole (0.025 g, 0.27 mmol), potassium carbonate (0.10 g, 0.72 mmol) and potassium iodide (0.09 g, 0.54 mmol) in acetonitrile (5 mL) was heated at 90 O for 18 h, cooled, then partitioned between water (30 mL) and DCM (3 x 20 mL). Thecombined organic extracts were dried and evaporated to give an oil. Chromatography (Si02,0 – 100% EtOAC in petrol gradient) gave the title compound (0.102 g) as an oil. MS: [M+H]= 602.
According to the analysis of related databases, 31722-49-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ASTEX THERAPEUTICS LIMITED; CHESSARI, Gianni; JOHNSON, Christopher Norbert; PAGE, Lee William; MILLEMAGGI, Alessia; HOWARD, Steven; SAXTY, Gordon; HEIGHTMAN, Thomas Daniel; WO2014/60768; (2014); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem