Application of 3034-50-2, These common heterocyclic compound, 3034-50-2, name is Imidazole-4-carbaldehyde, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of 3C (4.35 g, 21.16 mmol) in anhydrous dichloroethane (60 mL) was treated with imidazole-4-carboxaldehye (1B, 2.79 g, 28.99 mmol) and AcOH (0.35 mL, 6 mmol). The mixture was stirred at RT for 10 min and then treated with NaBH(OAc)3 (15.36 g, 72.48 mmol). The reaction mixture was stirred at RT overnight, and quenched with 2N NaOH solution, concentrated under vacuum. The residue was diluted with water (50 mL) and extracted with EtOAc (4¡Á100 mL). The organic layer was dried (MgSO4), filtered, and concentrated under vacuum. Chromatography (DCM containing 1 to 5% of 7N NH3 in MeOH) provided 3D (5.56 g, 89%). MS m/z 261 (MH+).
The synthetic route of 3034-50-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Schering Corporation and Pharmacopeia Drug Discovery, Inc.; US2007/93477; (2007); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem