1849-01-0, name is 1-Methyl-1H-benzo[d]imidazol-2(3H)-one, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. SDS of cas: 1849-01-0
Example 37; Preparation of Intermediate Compound 37A; To a solution of 2-bromo-4-carbomethoxythiazole (1.5 g, 6.78 mmol) in dioxane (80 mL) at room temperature was added 1 -methyl-2-benzimidazolone (1.0 g, 6.78 mmol) followed by CuI (0.13 g, 0.68 mmol), K2CO3 (1.0 g, 7.47 mmol), trans- N, lambda/-dimethylcyclohexane (0.21 mL, 1.35 mmol). The mixture was degassed under house vacuum and filled with N2 six times and heated to 90 C. The mixture was stirred for 12 hours, cooled to rt, and concentrated under reduced pressure. The EPO
The synthetic route of 1849-01-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SCHERING CORPORATION; WO2008/54749; (2008); A1;,
Imidazole – Wikipedia,
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