Some common heterocyclic compound, 137049-00-4, name is 1-Methyl-1H-imidazole-4-sulfonyl chloride, molecular formula is C4H5ClN2O2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 1-Methyl-1H-imidazole-4-sulfonyl chloride
2.2 Ethyl 1-(3,4-dichlorobenzyl)-7-(2-(1-methyl-1 H-imidazole-4-sulfonamido)ethoxy)- 1 ,2,3,4-tetrahydronaphthalen-2-ylcarbamate; Ethyl 7-(2-aminoethoxy)-1 -(3,4-dichlorobenzyl)-1 ,2,3,4-tetrahydronaphthalen-2- ylcarbamate hydrochloride (100 mg, 0.229 mmol) and DMAP (27.9 mg, 0.229 mmol) were dissolved in CH2CI2 (15 ml) and 1-methyl-1 H-imidazole-4-sulfonyl chloride (41.3 mg, 0.229 mmol) dissolved in CH2CI2 (15 ml) was added. The reaction mixture was stirred over night at RT. After addition of H2O the phases were separated and the aqueous phase was extracted with CH2CI2. The organic layer was washed with HCI (1 N), NaHCO3 solution and NaCI solution, then dried on MgSO4 and the solvent was removed. To the residue EtOAc/ diethylether (1 :1 ) was added, stirred, and the precipitate was separated by filtration to obtain a brown solid of product (100 mg). ESI-MS [M+H+] = 581.5 Calculated for C26H30CI2N4O5S = 580.13
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 137049-00-4, its application will become more common.
Reference:
Patent; ABBOTT GMBH &; CO. KG; AMBERG, Wilhelm; OCHSE, Michael; LANGE, Udo; KLING, Andreas; BEHL, Berthold; HORNBERGER, Wilfried; MEZLER, Mario; HUTCHINS, Charles; WO2010/92180; (2010); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem