Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 45676-04-8, name is 1-tert-Butylimidazole, A new synthetic method of this compound is introduced below., Product Details of 45676-04-8
THF (200 ml) and 1-tert-butylimidazole (12.42 g, 0.1 mol) were added into a 500 ml reactor containing a stirrer with N2 fully charged. After stirring evenly, the solution was cooled to -45 C. A solution of n-butyl lithium hexane (41.6 ml, 2.4 mol/L) was extracted with a 100 mL syringe and added slowly to the solution above while string. After stirring at -45 C. for 1 hour, the solution was raised to room temperature and kept stirring for 1 hour. Then, the solvent was removed by vacuum, and hexane (100 ml) was added in. 12.08 g (0.098 mol, 92.8%) product was obtained by remove the volatile components in vacuum after dispersion and filtration.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Tianjin University of Science&Technology; Jiang, Tao; Chen, Yanhui; Zhang, Le; Alam, Fakhre; Shao, Huaiqi; Li, Jian; Yan, Bing; (9 pag.)US2019/106366; (2019); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem