Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 10394-38-4, name is 1-Methylbenzoimidazol-5-amine, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 1-Methylbenzoimidazol-5-amine
To 6-(4-((2,5-dichloropyrimidin-4-yl)amino)piperidin-1-yl)pyridazine-3-carbonitrile (285.8 mg, 0.82 mmol)And 1-methyl-1H-benzo[d]imidazol-5-amine (149.1 mg, 1.01 mmol)Add in 1,4-dioxane (20mL) solutionPd(OAc) 2 (38.3 mg, 0.17 mmol),BINAP (98%, 106.0 mg, 0.17 mmol)Cs2CO3 (98%, 554.2 mg, 1.67 mmol). The resulting reaction system was stirred at 100 C overnight.After the reaction is completed, concentrated under reduced pressure. The residue obtained was purified by silica gel column chromatography (MeOH/DCM (v/v)=1/40).The title compound was obtained as a beige solid (233.3mg, yield 62%).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 10394-38-4.
Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Jiatuo Sciences Corporation; Xi Ning; Li Minxiong; Peng Ju; Li Xiaobo; Zhang Tao; Hu Haiyang; Chen Wuhong; Bai Changlin; Ke Donghua; Chen Peng; (217 pag.)CN109776522; (2019); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem