Synthetic Route of 1003-21-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1003-21-0, name is 5-Bromo-1-methyl-1H-imidazole, This compound has unique chemical properties. The synthetic route is as follows.
General procedure: 73: 2-methoxy-4-(1 -methyl-1 – -imidazol-5-yl)aniline Method F A suspension of 5-bromo-1 -methyl-1 H-imidazole (228 mg, 1.42 mmol), 2- methoxy-4-(4,4,5,5-tetramethyl-1 ,3,2-dioxaborolan-2-yl)aniline (423 mg, 1 .70 mmol), Pd(PPh3)4 (164 mg, 0.142 mmol) and CsF (645 mg, 4.25 mmol) in DME/MeOH (9/3 mL) was stirred at 150^ under microwave irradiation for 60 minutes. The reaction mixture was filtered and concentrated in vacuo. The residue was purified using Biotage silica gel column chromatography eluting with between 0-4% MeOH in EtOAc to afford the title compound (137 mg, 48%). 1 H NMR (500 MHz, CDCI3): delta 7.56 (s, 1 H), 7.02 (s, 1 H), 6.81 – 6.76 (m, 3H), 3.95 (s, broad, 2H), 3.88 (s, 3H), 3.64 (s, 3H). LCMS (ESI) Rt = 0.43 minutes MS m/z 204 [M+H]+
The chemical industry reduces the impact on the environment during synthesis 5-Bromo-1-methyl-1H-imidazole. I believe this compound will play a more active role in future production and life.
Reference:
Patent; CANCER RESEARCH TECHNOLOGY LIMITED; HOELDER, Swen; BLAGG, Julian; CHEUNG, Jack; ATRASH, Butrus; SHELDRAKE, Peter; WO2014/37751; (2014); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem