In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 67085-11-4, name is 4-(4-Chlorophenyl)-1-(1H-imidazol-1-yl)butan-2-ol belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 67085-11-4
(1) 3 kg of 1-(2-hydroxy-4-(4-chlorophenyl)butyl)-1-hydro-imidazole was dissolved in 30 kg of methylene chloride.3.5 kg of thionyl chloride was added dropwise at a rate of 1.5 ml/s at 20C and slowly warmed to 33C.The reaction was incubated for 1 hour, then refluxed at 60C for 1 hour, and slowly cooled to below 15C to obtain a reaction liquid;(2) In the reaction liquid obtained in step (1), add 10 C. water at a rate of 0.5 ml/s with stirring, and the volume ratio of the reaction liquid to water is 0.005:1, and then 1.0 to 1.5 kg/L. Add anhydrous sodium carbonate, suction filter, discard the solid,The liquid was concentrated at 55[deg.] C. until no dichloromethane was distilled off, dried and obtained.Upon detection, the yield of the product of this example was 99.18%. The target product and impurity levels were determined using HPLC and standards.The target product, 1-(2-chloro-4-(4-chlorophenyl)butyl)-1H-imidazole, was detected to be 99.17%.The content of 1-(1-chloro-4-(4-chlorophenyl)butan-2-yl)-1-hydro-imidazole is 0.53%.The 1-(2-hydroxy-4-(4-chlorophenyl)butyl)-1H-imidazole content was 0.12%.
The synthetic route of 67085-11-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Zhuzhou Qianjin Pharmaceutical Co., Ltd.; Peng Kaifeng; Zhang Yingshuai; Wen Fengqiu; Li Sanxin; Gong Yun; Li Fujun; (10 pag.)CN105175338; (2018); B;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem