Application of 4857-06-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4857-06-1, name is 2-Chloro-1H-benzo[d]imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
A mixture of 2-chloro-1H-benzo[d]imidazole (1.0 eq.) and ethanolamine (10 eq.) was heated to 200 C for 30 min by use of microwave irradiation. After the reaction was completed, the reaction mixture was cooled down to room temperature. The precipitated solid was filtered and washed with water to give desired product 2b. White solid (96% yield); mp 177.4 C; 1H NMR (400 MHz, CD3OD) delta 7.20-7.18 (m, 2H), 6.97-6.95 (m, 2H), 3.75 (t, J = 5.6 Hz, 2H), 3.49(t, J = 5.4 Hz, 2H); LRMS (electrospray) m/z (M+H)+ 178.
The synthetic route of 2-Chloro-1H-benzo[d]imidazole has been constantly updated, and we look forward to future research findings.
Reference:
Article; Oh, Sangmi; Kim, Sungbum; Kong, Sunju; Yang, Gyongseon; Lee, Nakyung; Han, Dawoon; Goo, Junghyun; Siqueira-Neto, Jair L.; Freitas-Junior, Lucio H.; Song, Rita; European Journal of Medicinal Chemistry; vol. 84; C; (2014); p. 395 – 403;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem