68892-07-9, name is Methyl 2-mercapto-1-methyl-1H-imidazole-5-carboxylate, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of Methyl 2-mercapto-1-methyl-1H-imidazole-5-carboxylate
To a mixture of example 159 (60 mg, 0.125 mmol, 1 equiv), methyl 2-mercapto-l-methyl-lH-imidazole-5-carboxylate (30.2 mg, 0,176 mmol, 1.4 equiv) and PPh3 (46.2 mg, 0.176 mmol. 1.4 equiv) in toluene (0.35 mL) at 0 C was added dropwise diethyl azodicarboxylate (40 % wt in toluene, 80 muEpsilon, 0, 176 mmol. 1.4 equiv). The mixture was stirred at rt for 3 h, concentrated, and then purified by column to give 79 mg (100%) of intermediate 161a as a white solid.
The synthetic route of 68892-07-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ARDELYX, INC.; LEWIS, Jason, G.; REICH, Nicholas; CHEN, Tao; JACOBS, Jeffrey W.; CHARMOT, Dominique; NAVRE, Marc; FINN, Patricia; CARRERAS, Christopher; SPENCER, Andrew; WO2013/96771; (2013); A1;,
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