Related Products of 10040-96-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 10040-96-7, name is 1-(4-Bromophenyl)imidazole, This compound has unique chemical properties. The synthetic route is as follows.
General procedure: To a solution of 4 (1.01 g, 1.22 mmol), CuI (23 mg, 0.12 mmol),PdCl2(PPh3)2 (45 mg, 0.064 mmol) and triethylamine (0.26 mL,1.86 mmol) in acetonitrile (10 mL), 2-amino-5-bromopyrimidine(635 mg, 3.65 mmol) were added. The reaction mixture wasrecharged with Ar and stirred at 80 C for 4 h in a sealed tube.The mixture was extracted with ethyl acetate and the organic layerwas washed with water and brine successively. The organic solventwas removed in vacuo. The residue was purified by column chromatography on silica gel (CH2Cl2/C2H5OH/NH3H2O, 10:0.6:0.1) toafford 20-OAc-3f (156 mg, 0.17 mmol, 13.9%).A solution of 20-OAc-3f (156 mg, 0.17 mmol) in MeOH (20 mL)was stirred at 65 C for 3H. The organic solvent was removed invacuo. The residue was purified by preparative TLC (petroleumether/acetone/triethylamine, 5:5:0.2) to yield analytically pureproduct 3f (14 mg, 0.015 mmol, 9.4%).
The chemical industry reduces the impact on the environment during synthesis 1-(4-Bromophenyl)imidazole. I believe this compound will play a more active role in future production and life.
Reference:
Article; Han, Xu; Lv, Wei; Guo, Si-Yang; Cushman, Mark; Liang, Jian-Hua; Bioorganic and Medicinal Chemistry; vol. 23; 19; (2015); p. 6437 – 6453;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem