Application of 20034-00-8, These common heterocyclic compound, 20034-00-8, name is (5-Nitro-1H-benzo[d]imidazol-2-yl)methanol, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
3.40b 2-chloromethyl-5-nitro-1H-benzimidazole 20 mL (275 mmol) thionyl chloride are added slowly to a solution of 6.4 g (33.1 mmol) (5-nitro-1H-benzimidazol-2-yl)-methanol in 100 mL DCM at 10 C. The reaction is stirred for 1 h at RT and the solvent is eliminated i.vac. The residue is triturated with DCM, suction filtered, washed with DCM and ether and dried in the circulating air dryer at 35 C. Yield: 7.01 g (100% of theory). C8H6ClN3O3 (M=211.609).
Statistics shows that (5-Nitro-1H-benzo[d]imidazol-2-yl)methanol is playing an increasingly important role. we look forward to future research findings about 20034-00-8.
Reference:
Patent; Boehringer Ingelheim Pharma GmbH & Co. KG; US2004/209865; (2004); A1;,
Imidazole – Wikipedia,
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