Application of 3034-38-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3034-38-6, name is 5-Nitro-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
A mixture consisting of 4-nitroimidazole (100 g, 884 mmol), sodium bicarbonate (164 g, 1.94 mol), and water (500 ml) was intensively stirred, and thereafter, bromine (106 ml, 2.07 mol) was added dropwise to the mixture at room temperature (23C to 25C) over 6 hours (wherein it intensively foamed during the dropping). The thus obtained mixture was further stirred under heating (50C to 55C, 4 hours). Thereafter, water (400 ml) and concentrated hydrochloric acid (80 ml) were added thereto under cooling on ice (10C or lower), and the obtained mixture was stirred for 1 hours. Crystals were collected by filtration. The obtained crystals were washed with water (on a filter paper, with 400 ml of water), dispersedly washed (with 800 ml of water, twice), and air-dried (50C, 16 hours). Yield: 213 g (Yield: 88. 9%), pale yellow crystal IR (KBr): 3074,1548, 1468, 1392, 1361,1345, 1310, 1259,1172, 1066,975, 830,667 cm~l.
The synthetic route of 5-Nitro-1H-imidazole has been constantly updated, and we look forward to future research findings.
Reference:
Patent; OTSUKA PHARMACEUTICAL CO., LTD.; WO2005/77913; (2005); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem