15965-31-8, name is 5-Chloro-1H-imidazole, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. HPLC of Formula: C3H3ClN2
To a solution of 4-chloro-1H-imidazole (180g, 1.76 mol, 1.00 eq) in dry dichloromethane (3.0 L) at 0C wasadded aq. NaOH (1 M, 2.11 L, 2.11 mmol, 1.20 eq) followed by tetra-n-butylammonium bromide (56.6 g, 0.176 mol, 0.10 eq). To this biphasic solution was added dropwise allyl bromide (167 mL, 1.93 mol, 1.10 eq) and the resulting mixture was stirred at room temperature for 20h. Thereafter the reaction mixture was diluted withwater (1 L), extracted with dichloromethane (2 x 1 L), the combined organic layers were dried (Mg504) and concentrated in vacuo, to provide 290 g of a mixture of regioisomers (80% purity, 93% yield), which were separated by distillation at reduced pressure (0.1 mbar). MS (El): 142.1 ([M])
The synthetic route of 15965-31-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BAYER CROPSCIENCE AKTIENGESELLSCHAFT; BAYER AKTIENGESELLSCHAFT; COQUERON, Pierre-Yves; BERNIER, David; WACHENDORFF-NEUMANN, Ulrike; GOeRTZ, Andreas; DAHMEN, Peter; DUCROT, Virginie Pascale; (195 pag.)WO2018/50456; (2018); A1;,
Imidazole – Wikipedia,
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